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This finding underscores the need for new molecules or modifications to MF to overcome MT-Ros3 dependence and enhance treatment efficacy ( Leishmania exhibits remarkable stability, as indicated by a consistent EC50 value, even after prolonged culture without drug exposure
Based on the current level of evidence, other authors have also suggested the use of oral or topical glutathione as an adjunctive therapy for facial melanosis
Karonitsch, T